Sunday, February 3, 2013

Super Bowl of firsts, lasts, bests

A statue depicting the Vince Lombardi Super Bowl Trophy stands outside the Mercedes-Benz Superdome at sunset on Friday, Feb. 1, 2013, in New Orleans. The Baltimore Ravens are to play the San Francisco 49ers in NFL football's Super Bowl XLVII on Sunday at the Superdome. (AP Photo/Gene J. Puskar)

A statue depicting the Vince Lombardi Super Bowl Trophy stands outside the Mercedes-Benz Superdome at sunset on Friday, Feb. 1, 2013, in New Orleans. The Baltimore Ravens are to play the San Francisco 49ers in NFL football's Super Bowl XLVII on Sunday at the Superdome. (AP Photo/Gene J. Puskar)

The Superdome, where the NFL Super Bowl XLVII football game between the San Francisco 49ers and Baltimore Ravens will be played, is seen at sunset Friday, Feb. 1, 2013, in New Orleans. (AP Photo/Charlie Riedel)

San Francisco 49ers head coach Jim Harbaugh and Baltimore Ravens head coach John Harbaugh participate in a news conference for the NFL Super Bowl XLVII football game Friday, Feb. 1, 2013, in New Orleans. (AP Photo/Patrick Semansky)

Baltimore Ravens linebacker Ray Lewis walks out to an NFL Super Bowl XLVII practice on Friday, Feb. 1, 2013, in Metairie, La. The Ravens face the San Francisco 49ers in Super Bowl XLVII on Sunday, Feb. 3. (AP Photo/Patrick Semansky)

A banner hangs from a balcony on Bourbon Street in tribute to Baltimore Ravens linebacker Ray Lewis, who is retiring as a player after Sunday's NFL football Super Bowl football game between the San Francisco 49ers and the Ravens, Friday, Feb. 1, 2013, in New Orleans. (AP Photo/David Goldman)

(AP) ? The journey to this Super Bowl wound through bounties and replacement refs, eventually bringing the big game back to the Big Easy ? with a replacement quarterback, a sibling rivalry and a grand exit for one of the NFL's greatest players, clouded by the obscure healing powers of deer-antler spray.

It is a Super Bowl of comebacks, of firsts and lasts, and ? if San Francisco wins ? the best.

A win over the Baltimore Ravens on Sunday gives the 49ers six championships, matching Pittsburgh's titles in the Super Bowl era. Unlike the Steelers, the Niners have never lost one.

Of course, they haven't won one in 18 years, either.

"There's a tradition with the San Francisco 49ers, but I think these guys are paving their own way," said Hall of Fame receiver and three-time champion Jerry Rice. "They're playing with a lot of swagger."

Or as owner Denise DeBartolo York said, "We've come full circle and the dynasty will prevail."

New Orleans has come full circle, too. Ravaged by Hurricane Katrina in August 2005, losing a quarter of its population, abandoned by the Saints for an entire season, the city couldn't imagine hosting another Super Bowl. But as New Orleans recovered and rebuilt, it envisioned staging what Patriots owner Robert Kraft calls "the pre-eminent sporting event."

The NFL agreed it was time to return. And even if Commissioner Roger Goodell is despised here after slapping the Saints with suspensions and fines in the bounty scandal, the vibes from the French Quarter and Warehouse District this week have been supportive, even uplifting.

"It's also terrific for us to be back here in New Orleans," Goodell said, joking about voodoo dolls in his likeness. "Our 10th Super Bowl here, the first since Katrina, and it's clear this city is back bigger and better than ever."

There's the tale of the head coaching brothers, Baltimore's John and San Francisco's Jim, the first siblings to face off in a Super Bowl. And Ray Lewis, the pre-eminent linebacker of his generation on his self-proclaimed last ride. (His farewell party was somewhat sidetracked for two days this week when Lewis waved off a report that he tried to get unusual products like deer-antler spray to speed his recovery from an arm injury that sidelined him for 10 games.)

"There are so many storylines to this game that make it bigger than just the Super Bowl," 49ers CEO Jed York said.

Such as the Harbaughs plot about sons of a lifetime coach who took different paths to the top of the NFL.

John, older by 15 months, has made his career standing on the sideline with a headset. He's the only head coach to win playoff games in his first five seasons; his quarterback, Joe Flacco, has the same distinction as he heads into his first Super Bowl. Jim Harbaugh was a first-round draft pick and quarterbacked four teams in 14 pro seasons before going into coaching. He was an immediate success at San Diego ? the Toreros in the college Pioneer League, not the Chargers in the NFL ? and Stanford before the 49ers won a bidding war for him in 2011.

This week's family reunion has been light-hearted, though that figures to change Sunday.

"It's probably a little tougher emotionally," John Harbaugh said of facing his brother. "It's a little tougher just from the sense of I don't think you think about it when you're coaching against somebody else; it's more about the scheme and the strategy. There's a little bit of a relationship element that's more strong than maybe coaching against someone else.

"I'll have a better answer for you after the game. I've never been through this before. This is all new."

And oh-so-new for the QBs, Flacco and Colin Kaepernick.

Flacco is no fluke, holding the career record for road playoff wins with six. But until outplaying Peyton Manning and Tom Brady this year, he hadn't gotten the Ravens to the Super Bowl. He has eight touchdown passes and no interceptions in the postseason, padding a resume that soon will make him one very highly paid quarterback: Flacco's contract expires after this game. Even with a franchise tag applied by Baltimore (13-6), he'll make about $14.6 million next season.

"I think when you talk about winning as quarterbacks in the playoffs," Flacco said, "I would think that all of them have Super Bowl victories. So that's really the only one that matters, and that's what we're trying to get."

Naturally, so are the 49ers (13-4-1), whose midseason adoption of the pistol offense to best use Kaepernick's dynamic versatility added a dimension no one has been able to stop. The Niners might never have taken such a huge step had incumbent Alex Smith, in the midst of his best season, not sustained a concussion on Nov. 11. Kaepernick took over and the offense took off.

Once Smith was healthy, he no longer was the starter. Jim Harbaugh gambled by sticking with the raw second-year quarterback who brought more game-breaking skills to the position.

Difficult decisions like that are sometimes foolhardy, sometimes inspired.

This one worked superbly, and Kaepernick stands one victory from joining Joe Montana and Steve Young as a 49er Super Bowl champion.

"It was tough watching this team do well and not being able to contribute," said Kaepernick, more recognized before his promotion for his collection of tattoos than for his strong arm and sprinter's speed. "For me, what kept me going was the fact that I might get an opportunity to get out there. When I did, I needed to take advantage of it."

The 49ers hope to take advantage in the same Superdome where they were at their most dominant, beating Denver 55-10 in 1990 in the biggest rout the Super Bowl has seen.

The Steelers are recognized as the true powerhouse of the Super Bowl era, which is nearly a half-century old. Four of those titles came in the 1970s, with Mean Joe Greene and the Steel Curtain shutting down opponents while Terry Bradshaw, Franco Harris and Lynn Swann were scoring on them.

But the last two were in 2005 and 2008, and they've been perennial playoff qualifiers, too. That kept them in the football forefront.

For the 49ers the golden years of Montana, Rice, Young and Ronnie Lott ended with the 1994 season. They didn't even make the playoffs from 2003-10, and this is their first trip back to the Super Bowl.

Rice sees Super Bowl win No. 6 coming Sunday.

"I just think we had players who played well in the big game," he said. "My best football that I played, I think, happened in the playoffs and in the Super Bowl. I think it's the same with these players."

None of whom, except for center Jonathan Goodwin and linebacker Clark Haggans, has won a title. That's still one more ring than the Ravens have: Lewis is the sole NFL champion in Baltimore.

Lewis hungers for these teammates to taste their first title ? and to do it in his last game.

"I've touched the Lombardi (Trophy), and I know how it feels," the perennial All-Pro said. "For these guys who've made this journey with me to feel that, it would be the perfect ending for my career."

Like Lewis, 49ers receiver Randy Moss also could be suiting up for the final time, although he hopes to play another year.

Grabbed off the scrap heap after his career spiraled into oblivion and no team would touch him in 2011, Moss didn't do much on the field (28 catches, 434 yards) this season. His loudest headlines came this week when he proclaimed himself the greatest receiver ever; maybe he's never seen Rice's numbers.

Teammates say Moss was very influential as a mentor and teacher.

"Randy's like my older brother," said Michael Crabtree, who emerged as a top receiver in his fourth pro season. "An older brother you would have that's been through a lot that you just can learn from just talking to him, watching him.

"He's a legend and I hope he'll be here next year."

Lewis won't be. He'll don the face paint, put on his No. 52 for the final time, and see if he can replicate the championship of a dozen years ago.

"You can never top the first one, because that's an unknown feeling," Lewis said before adding with a chuckle, eyes widening, "but a second one ? that might be the only way you really can top it."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-03-FBN-Super-Bowl/id-e0c76b722a4248c7bc76213ec9babc92

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Carolina LB Kuechly is top rookie

(AP) ? Linebacker Luke Kuechly, Carolina's tackling machine, has won the Associated Press 2012 NFL Defensive Rookie of the Year award.

Kuechly, a first-round pick from Boston College, led the league with 164 tackles. He began the season on the outside but moved to middle linebacker five games into the season and the Panthers went from 24th in the league in overall defense to 10th.

He earned 28 votes from a nationwide panel of 50 media members who regularly cover the league. That easily outdistanced Seattle LB Bobby Wagner with 11.

Green Bay cornerback Casey Hayward got six votes, while St. Louis CB Janoris Jenkins got three. Tampa Bay LB Lavonte David got the other two votes.

He is the second Panther to win the award; DE Julius Peppers got it in 2002.

Kuechly accepted his award Saturday night at the "2nd Annual NFL Honors" awards show on CBS saluting the NFL's best players, performances and plays from the 2012 season.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-02-FBN-NFL-Defensive-Rookie/id-f63c975818424871a76e5b3a1d1afc7e

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Engineered oncolytic herpes virus inhibits ovarian and breast cancer metastases

Jan. 31, 2013 ? A genetically reprogrammed Herpes simplex virus (HSV) can cure metastatic diffusion of human cancer cells in the abdomen of laboratory mice, according to a new study published January 31 in the Open Access journal PLOS Pathogens. The paper reports on the collaborative research from scientists at the at the University of Bologna and specifically describes that the HSV converted into a therapeutic anticancer agent attacks breast and ovarian cancer metastases.

Past decades have witnessed significant progress in the ability to treat numerous cancers by means of surgery, chemo- and radio-therapy, or combinations thereof. However, many treatments prolong life for a short time only, or are associated with a poor quality of life.

Lead investigator Gabriella Campadelli-Fiume and colleagues re-engineered the entry apparatus of a candidate oncolytic herpesvirus. The reprogrammed virus no longer infects the cells usually targeted by the wild-type virus, nor does it cause herpes-related pathologies. Rather, it acts as a specific weapon against tumor cells that express the HER-2 oncogene.

"Numerous laboratories worldwide are using viruses as more specific weapons against cancer cells, called oncolytic viruses," says Campadelli-Fiume, Professor of Microbiology and Virology. "Safety concerns prevailed so far, and all oncolytic herpesviruses now in clinical trials are debilitated viruses, effective only against a fraction of tumors. We were the first to obtain a herpes virus reprogrammed to enter HER-2-positive tumor cells, unable to infect any other cell, yet preserves the full-blown killing capacity of the wild-type HSV."

Additionally, the laboratory of Pier-Luigi Lollini, Patrizia Nanni and Carla De Giovanni in collaboration with researchers at the Rizzoli Institute, established the new model of human cancer metastases in mice that was used to demonstrate the therapeutic efficacy of the reprogrammed virus.

The positive results obtained in the treatment of experimental metastasis hold the promise that the newly retargeted oncolytic HSV described in PLOS Pathogens is a good candidate to become a novel type of cancer treatment, and represents a key step forward in the path to clinical trials for late stage human breast and ovarian cancers.

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The above story is reprinted from materials provided by Public Library of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Patrizia Nanni, Valentina Gatta, Laura Menotti, Carla De Giovanni, Marianna Ianzano, Arianna Palladini, Valentina Grosso, Massimiliano Dall'Ora, Stefania Croci, Giordano Nicoletti, Lorena Landuzzi, Manuela Iezzi, Gabriella Campadelli-Fiume, Pier-Luigi Lollini. Preclinical Therapy of Disseminated HER-2 Ovarian and Breast Carcinomas with a HER-2-Retargeted Oncolytic Herpesvirus. PLoS Pathogens, 2013; 9 (1): e1003155 DOI: 10.1371/journal.ppat.1003155

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/IZqPRKXO0hE/130201090820.htm

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Greek political parties to testify over bank loans

ATHENS (Reuters) - Greek prosecutors have ordered the two main ruling parties to testify in an investigation into more than 200 million euros in loans they received from banks, officials said on Friday.

The investigation - which is examining whether the loans are legal and whether any wrongdoing was involved - could embarrass the fragile conservative-led government, which relies on aid from the European Union and the International Monetary Fund.

Last year a Reuters report revealed the conservative New Democracy and the Socialist PASOK parties were close to being overwhelmed by debts of more than 200 million euros as they face a slump in state funding because of falling public support.

Senior officials from the two parties will appear before financial crime prosecutors on February 18, court officials said.

"They will be investigated for suspected crimes against the state," said a court official who declined to be named. The prosecutors are also looking into the finances of the Communist KKE party, the court official said.

A PASOK official confirmed the party had been asked to testify, but declined to comment on the case.

Prime Minister Antonis Samaras' New Democracy party did not immediately respond to a call for comment. The party has previously said the bulk of its loans were being paid on time, and only a small part of the loans may have become late or non-performing.

Like other EU parties, Greek parties get state funding depending on their share of the vote. Relying on strong results in the past, New Democracy and the Socialist PASOK had pledged future state funding as collateral for bank loans.

Banking sources familiar with the issue told Reuters in September that the two parties combined owe 232 million euros to Greek banks and some of the loans are going unpaid.

In a June vote, support for the two parties which have dominated Greek politics for decades collapsed, leaving them with loans and facing much smaller incomes. PASOK saw its support plunge from 43 percent to 12 percent, while New Democracy's share fell from 33 percent to 29 percent.

Greece, which is implementing austerity measures demanded by its foreign lenders in return for aid to keep afloat, spent 65 million euros in 2010 and 54 million euros in 2011 to fund parties. In 2012, the two ruling parties received 11 million euros, based on the results of the 2009 election.

(Reporting by Renee Maltezou; Editing by Stephen Powell)

Source: http://news.yahoo.com/greek-political-parties-testify-over-bank-loans-174009895--finance.html

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Eve 6: Curtain

Remember Eve 6? Those were the days. No, I'm not talking about "Here's To the Night" playing at some high school dance. I'm talking about "Inside Out," or the under appreciated never-a-single "How Much Longer." Turns out those guys are still kicking, and the relatively new single "Curtain" ain't half bad. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/9GDNxzmjTsg/eve-6-curtain

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Saturday, February 2, 2013

MyFeePlan to Begin Offering Public Military Records to Their Customers

MyFeePlan.com will start to offer military records along with continued service of other valuable public records.

San Diego, CA (PRWEB) January 31, 2013

MyFeePlan has expanded the scope of their public records database to include military records, company officials said yesterday.

?We have had numerous requests from our customers to make military records available to them,? said company spokesman Josh Fraser. ?It took us some time to add them to the database, but they are now there and we are happy to have the chance to find a new way to satisfy our customers.?

MyFeePlan is a public document search company. In the past they have offered arrest records, warrant checks, driving records checks, sex offender checks, and vehicle history reports to the general public.

?This is just one more way for us to make sure that information that is supposed to be public remains available to the public," Fraser said. ?Your tax dollars were used to generate these records, so you should be able to have access to them.?

Fraser said there were a variety of reasons that people may want to use a military records check.

?Maybe you've lost touch with an old army buddy and want to locate him,? Fraser said. ?Or maybe someone has applied for a job at your company and claims to have a stellar military record. Wouldn't you want to find out for sure if they are telling the truth, or if they left the military for less than honorable reasons??

The company said that as the wars in Iraq and Afghanistan continue to wind down and soldiers come home, he expects there the demand for military records checks to continue to grow.

?The people asked for them and we've found a way to give it to them,? he said.

About MyFeePlan.com:

MyFeePlan.com is a customer service solution for public records services like background checks, vehicle history reports, criminal checks, driving records, arrest records, etc. They provide 24/7 live chat and phone support with REAL, professional customer service representatives.

Josh Fraser
MyFeePlan.com
1-888-361-7496
Email Information

Source: http://news.yahoo.com/myfeeplan-begin-offering-public-military-records-customers-081456554.html

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Friday, February 1, 2013

96% West of Memphis

All Critics (71) | Top Critics (18) | Fresh (68) | Rotten (3)

Happy, sad, inspiring, infuriating, right and terribly wrong, all at the same time.

Berg's film is as much an indictment of the state of Arkansas' legal system as it is the prosecution.

Berg's film helps illuminate a case that should certainly be the shame of the state of Arkansas, and perhaps the criminal justice system of the entire United States.

Dubious evidence; suspicious confessions; conveniently located "poor white trash" (Echols' words) to take the rap: The case stank from the beginning, Berg's film argues.

Less an investigative report than a portrait of the community that forms around an ongoing court case, this conveys a patient understanding of the intricacies of law and human behavior that may be termed Kieslowskian.

"West of Memphis" is the fourth film about one of the most heinous cases of wrongful conviction in American judicial history. Do we need a fourth film? Yes, I think we do.

A frankly extraordinary document about the three innocent children who were murdered in West Memphis, Arkansas and the three innocent teenagers who spent 18 years in prison for the crime.

(Director Amy) Berg's doc is gripping, often infuriating, but in the end hopeful about the ability of truth and innocence to prevail thanks to the efforts of those who strive against all obstacles to uphold them.

The new film is largely a recap of the older ones, with more celebrity testimonials and fewer Metallica songs but little fresh insight into the miscarriage of justice it chronicles.

Extols the efforts of celebrities to win the release of three innocent men [and is] suspenseful when it's straightforward-the best CSI investigation that money can buy.

Nearly overwhelms you with hopelessness, if not an adrenaline rush of rage - even if you're familiar with the case.

It's a beautifully done piece of work in its own right, yet viewed beside the trilogy which preceded it, it comes across a bit like "Paradise Lost 3b - the Celebrity Edition."

A whodunit in which truth devastatingly becomes a luxury.

New evidence and a fresh perspective keep the subject matter compelling.

Filmmaker Amy Berg (Oscar nominated Deliver Us From Evil) has once again struck documentary gold with her hard-hitting journalistic feature, West of Memphis.

A lot of it is treading on ground that's been laid by other people, but there's a lot of great new stuff, too.

The infuriating facts in this famous case are illuminated with new human detail.

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Source: http://www.rottentomatoes.com/m/west_of_memphis/

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