Oxidative stress and altered gene expression occurs in a metabolic liver disease model

ScienceDaily (Oct. 29, 2012) ? A team of researchers under the direction of Dr. Jeffrey Teckman in the Department of Pediatrics at St. Louis University, have demonstrated that oxidative stress occurs in a genetic model of alpha-1-antitrypsin deficiency. This is the most common genetic liver disorder in children and can lead to cirrhosis and hepatocellular carcinoma in adults. Some cases may require liver transplantation.

The report, published in the October 2012 issue of Experimental Biology and Medicine, suggests that treatment with antioxidants might be of therapeutic benefit for some individuals.

"We have evidence of oxidative stress in livers from an animal model that expresses the classical Z variant form of alpha-1-antitrypsin. The animal model recapitulates the human liver disease, in which the livers accumulate polymers of alpha-1-antitrypsin mutant Z protein, developing fibrosis and hepatocellular carcinoma with age," says Dr. Marcus. Potentially, non-invasive treatment involving long-term regulation of antioxidant levels could ameliorate the oxidative stress and retard the advancement of disease.

"This is an exciting new report which may help us understand the extreme variability between different patients with this same, single gene, metabolic liver disease. These findings may inform the pathophysiology of other liver diseases as well," says Dr. Teckman. In clinical studies, liver disease from alpha-1-antitrypsin mutant Z protein has shown considerable variability in severity and progression, suggesting that as yet undescribed genetic modifiers may influence disease development. Based on this study, certain antioxidant enzymes involved in oxidative stress defense could be useful targets for further examination. Using microarray technology, the investigators have identified a number of potential alterations in gene expression pathways that could modify the development of liver pathologies. This information could be useful in defining genetic variants that may influence individual susceptibility and in facilitating the design of appropriate treatments.

Steven R. Goodman, PhD, Editor-in-Chief of Experimental Biology and Medicine said, "Teckman and colleagues have demonstrated that oxidative stress occurs in an animal model of Alpha-1-antitrypsin deficiency. This suggests that antioxidant treatment may be beneficial in this most common genetic liver disorder in children."

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The above story is reprinted from materials provided by Society for Experimental Biology and Medicine, via EurekAlert!, a service of AAAS.

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Journal Reference:

1. N. Y. Marcus, K. Blomenkamp, M. Ahmad, J. H. Teckman. Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency. Experimental Biology and Medicine, 2012; DOI: 10.1258/ebm.2012.012106

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/aG8p31SCRz8/121030062609.htm

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Meek Mill Says Debut Album Will 'Sustain Itself,' Despite Sandy

'I ain't really trippin' on the first week, man,' Meek tells MTV News of storm's potential effect on Dreams & Nightmares sales.
By Maurice Bobb

Meek Mill
Photo: FilmMagic

Source: http://www.mtv.com/news/articles/1696540/hurricane-sandy-meek-mill-dreams-and-nightmares-album-sales.jhtml

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Small Loans Show Growth Potential | Finance Buzz - Personal ...

For those of us who have been around for a few years, it?s pretty clear that banking is one industry that has been through some significant changes, especially when it comes to personal loan applications. Gone are the days when you would approach the bank manager directly and plead your case to improve your cash flow situation. These days the bank manager has nothing to do with the final decision and banks are only really interested in a minimum of $5,000 if you want to borrow.

The argument against small loans it that the average $3,300 loan taken over a year racks up an additional $462 in admin fees plus an establishment fee so it doesn?t make good business sense for banks to go to the trouble of offering the service. For consumers who have overextended their credit cards and have a bad credit rating the current lending climate is a pretty aggressive place and going through the banks could be a futile endeavour so it is just as well that there are more accessible options opening up for loans, such as the ones at Bankwest.com.au (http://www.bankwest.com.au/personal/personal-loans/personal-loans-overview), which our research led us to.

What is more, Cash Converters? personal loan growth of 31 per cent to $62.1-million is also worth a mention because the model it was built on was geared towards market needs. Its core business is extending $1,000 loans on a shorter term of seven months, accumulating $490 in interest and a $250 establishment fee. Australia?s short term small amount market is estimated to be generating more than $1-billion and, for those who are running out of viable loan options it provides a suitable channel.

Things are looking up for the cash-strapped consumer though as legislation has also recently been passed that restricts the interest and charges that can be applied to small, short term loans. Loans under $2,000 have been capped at 20 per cent of the credit amount to be charged upfront and 4 per cent on a monthly basis for the term of the loan.

Other developments in the arena of personal loan financing have seen the emergence of a new peer-to-peer platform released by SocietyOne. It is a loan management program called ClearMatch which caters to a changing world with a dynamic online solution and a secure framework through which borrowers? and investors? interests can be satisfied.

The new platform promises a more efficient personal loan process by taking the middle man, the bank, out of the borrower-investor relationship. It has also been claimed that the operating platform?s technology is more efficient than can be expected at a bank and other financial lending institutions.

The news of the software?s Australian debut comes in the wake of its success in the United Kingdom, and SocietyOne feels it is likely to have the same degree of impact down under. The software creates a mutually beneficial framework, as borrowers pay lower fees and interest and lenders can access an asset class that has kept the banks running for many years.

In its favour is fixed rate monthly interest and repayments. There is also no monthly charge and no fees apply for early repayment. The funds are provided by independent investors who invest small amounts into different accounts to create a diverse portfolio under the management of SocietyOne. Borrowers can access to up $30,000, on what has been coined a responsible borrowing option.

So if there wasn?t already enough pressure on the banks the introduction of more direct borrowing alternatives poses a threat to their precarious profit margins. The country?s big four have come under a lot of fire recently, monopolizing the market and charging Australians significantly higher interest rates and fees than their financial counterparts in the rest of the developed world.

Source: http://www.financebuz.com/2012/10/small-loans-show-growth-potential.html

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The Business Benefits of the HIPPA Cloud

HIPAA-compliant solutions are in the end the task of the CE which must meet all of the following criteria: Identification and Authorization which is the process of correctly identifying and authenticating users, Authorized Privileges and Access Control whereby authorizations or privileges can be obtained, Confidentiality whereby access controls have to ensure that there is no accidental or unauthorized disclosure of data such as using encryption, Integrity which is the measures to ensure that data does not get unintentionally or maliciously altered, and accountability which is the tracking actions or behaviors of users such as using auditing to learn how data is accessed.

All organizations involved with credit card processing are required to comply with the PCI Data Security Standard. For enterprises in service in such areas as financial services, retail, healthcare, etc, PCI compliance has become a costly and time consuming task. PCI audits can cost hundreds of thousands of dollars and many businesses are unsuccessful in their first attempt to attain PCI certification. One of the best solutions to become PCI compliant is to acquire HIPPA Cloud Solutions.

A business must create an infrastructure that complies with PCI regulations. When you take advantage of the HIPPA Cloud, the PCI Cloud Host you choose should partner with Approved PCI Scanning Vendor (ASV) services. The scanning service includes an evaluation of the code on your site and looks for any risks. With HIPPA Cloud, you will benefit from a properly configured Firewall and Intrusion Detection System (IDS), and if your site is accessed by the public you must separate the credit card information from the public information via a De-Militarized Zone (DMZ) which you can do with the HIPPA Cloud hosting. A good PCI managed cloud will employ Microsoft Internet Security and Acceleration (ISA) for Windows systems and Cisco Adaptive Security Appliances (ASA) for Linux-based systems.

A reputable and qualified PCI Cloud Host company offers the most extensive PCI compliance solutions. The PCI DSS standard focuses on twelve major compliance areas that includes - software design, security management, policies, network architecture, procedures, etc, of which ten areas are can be addressed by a PCI Managed Cloud Host. An all-inclusive PCI cloud host compliance program addresses all ten of the service provider qualified compliance areas. With a good PCI cloud host, your business will benefit from a service that offers a turn-key PCI start-up package that includes PCI compliant networking equipment, virus scanning, database layer DMZ, intrusion detection services, fully dedicated redundant architecture, , and authentication services.

A worthwhile and qualified PCI Managed Host will provide PCI ongoing maintenance that includes: system level vulnerability testing, log review and management, intrusion detection, system level vulnerability testing, and change management. PCI managed hosting offers effective PCI compliance solutions that will help your business meet all compliance standards. Any company processing, storing, or transmitting payment card data must comply with the Payment Card Industry Data Security Standards (PCI DSS). If not, a merchant could lose their ability to process credit card payments and will likely be fined by their attaining bank/processor. HIPPA Cloud Solutions are designed to help businesses maintain compliance and prevent hacking, credit card fraud, and other security risks.

Dedicated to solving problems for clients, we provide solution. Offers various hosting such as Managed cloud, Private Cloud hosting and HIPAA hosting. Visit us and see

Dedicated to solving problems for clients, we provide solution. Offers various hosting such as http://www.logicworks.net/Solutions/Cloud-Computing Managed cloud, Private Cloud hosting and http://www.logicworks.net/Applications/Health-Care HIPAA hosting. Visit us and see

Source: http://www.articlesbd.com/articles/266743/1/The-Business-Benefits-of-the-HIPPA-Cloud/Page1.html

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Kuwait arrests opposition leader over emir comments

KUWAIT (Reuters) - Kuwaiti authorities arrested an opposition leader late on Monday after he made comments viewed as critical of the Gulf Arab state's ruler, a political activist said.

Musallam al-Barrak, a former lawmaker and a prominent figure in the nationalist Popular Action Bloc, was arrested on Monday night following a news conference at his house where he called on the government to abide by the constitution.

His arrest seems likely to fuel political tensions in the oil exporting state, which has seen some violent protests in recent weeks following changes to the country's electoral law that critics say will hamper the opposition in a parliamentary ballot scheduled for December 1.

At an opposition-led rally on October 15 where Kuwaiti civilians clashed with riot police, Barrak appealed to Emir Sheikh Sabah al-Ahmad al-Sabah to avoid "autocratic rule".

Although Kuwait allows more freedom of speech than some other Gulf states, the emir, who has the last say in state affairs, is considered "immune and inviolable" in the constitution.

"Members of the state security service came in with an arrest warrant and he (Barrak) is now being held at the state security department," activist Ahmad al-Dayeen told Reuters.

He described the arrest as a serious development that could have an impact on protest rallies scheduled for November 4.

With the uprisings which have swept through much of the Arab world aggravating tensions between Kuwait's elected parliament and a government dominated by the Al-Sabah ruling family, the OPEC member state has shown limited tolerance for dissent.

Last week, authorities released three former opposition lawmakers accused of criticising the emir and four people arrested for taking part in protests this month. A court hearing for the former MPs was set for November 13.

Tens of thousands protested the electoral law reforms, which were ordered by the emir, leading to some of the worst violence in the country's recent history.

The opposition has said it will boycott the December 1 election.

Kuwait's oil wealth and generous welfare state has helped it avoid the kind of uprisings that toppled leaders elsewhere in the region.

On Monday, credit agency Fitch warned Kuwait on that further escalation of political protests could put its AA sovereign rating under pressure despite the nation's strong balance sheet.

(Reporting by Ahmed Hagagy; Writing by Rania El Gamal; Editing by John Stonestreet)

Source: http://news.yahoo.com/kuwait-arrests-opposition-leader-over-emir-comments-073028855.html

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Fans fill SF streets to celebrate Giants' win

San Francisco Giants fans cheer for their team following the Giants 4-3 victory over the Detroit Tigers in Game 4 of baseball's World Series on Sunday, Oct. 28, 2012, in Detroit. The Giants won the World Series 4-0. (AP Photo/The Sacramento Bee, Randy Pench) MAGS OUT; LOCAL TV OUT (KCRA3, KXTV10, KOVR13, KUVS19, KMAZ31, KTXL40); MANDATORY CREDIT

San Francisco Giants fans cheer for their team following the Giants 4-3 victory over the Detroit Tigers in Game 4 of baseball's World Series on Sunday, Oct. 28, 2012, in Detroit. The Giants won the World Series 4-0. (AP Photo/The Sacramento Bee, Randy Pench) MAGS OUT; LOCAL TV OUT (KCRA3, KXTV10, KOVR13, KUVS19, KMAZ31, KTXL40); MANDATORY CREDIT

A San Francisco Giants fan jumps over a bonfire in San Francisco's Mission district Sunday, Oct. 28, 2012, after the Giants swept the Detroit Tigers to win baseball's World Series. (AP Photo/Noah Berger)

San Francisco Giants fan David Zweig celebrates outside PacBell Park on Sunday, Oct. 28, 2012, in San Francisco after the Giants swept baseball's World Series against the Detroit Tigers. (AP Photo/Noah Berger)

San Francisco Giants fans celebrate outside PacBell Park on Sunday, Oct. 28, 2012, in San Francisco after the Giants swept baseball's World Series against the Detroit Tigers. (AP Photo/Noah Berger)

San Francisco Giants fans celebrate outside PacBell Park on Sunday, Oct. 28, 2012, in San Francisco after the Giants swept baseball's World Series against the Detroit Tigers. (AP Photo/Noah Berger)

SAN FRANCISCO (AP) ? Thousands of baseball fans took to the streets of San Francisco to celebrate the Giants World Series victory, with revelers gathering on corners, in parks and at watering holes as car horns blared long into the night.

Fans across the city left their televisions and rushed outside, greeting diners, bar patrons and other merry makers Sunday night after the Giants defeated the Detroit Tigers 4-3 to sweep the Series for their second title in three years.

Small fires broke out in trash cans here and there, but the violence and vandalism appeared to have been kept to a minimum a few hours after the last pitch.

"We're watching out for any major flareups and fires," said police spokesman officer Carlos Manfredi. "We want to maintain public safety at all times, and don't want to put first responders in any danger."

He said police were responding to certain hot spots but had no reports of serious problems. No arrest figures were available.

KGO-TV reported that at least three bonfires flared on Mission Street with fans fueling them with couches, signs, newspaper racks, and other items. Firefighters had to be escorted in by riot police to fight some of the fires.

At Polk and Bush streets in the city's Polk Gulch neighborhood, hundreds of fans sprayed champagne, set of off firecrackers and blocked traffic for at least two hours after the game.

Several blocks away, police clad in riot gear looked on as revelers danced around Civic Center plaza where they watched the game on the Jumbotron.

The thousands of fans assembled there exploded in a roar with the final out.

Anthony Yos, 10, hugged his brother Luciano Yos, 15 and the two danced in an embrace with their parents.

"This is the greatest thing," Anthony said with a smile that could go no wider. "The Giants are my favorite team."

Someone in the crowd launched fireworks a few minutes after the game and the park was awash with fans, strangers hugging strangers and wine bottles and marijuana cigarettes being freely passed through the crowd despite a heavy police presence.

"This is San Francisco, "said Laura Chu. "We know how to party."

Sara Vivas brought her 6-year-old daughter Briana Cepeda from Oakland to view the game and join the celebration. They were both clad head-to-toe in Giants garb.

"This is something she will remember forever," Sara said.

Bars of all stripes, from the Castro to Chinatown were packed with supporters of the beloved Giants.

So-called pedicabs whisked fans down roads blocked to traffic and revelers enjoyed a New Year's Eve-like freedom to roam up and down streets usually clogged with traffic.

Mayor Edwin Lee announced the ticker-tape parade would be held Wednesday at 11 a.m., down Market Street to Civic Center Plaza

"The rain in Detroit couldn't dampen the drive, talent and determination of the San Francisco Giants team tonight. Once again, the Giants brought our City together as we all cheered on our hometown heroes to another remarkable World Series victory," he said.

The 2010 parade drew hundreds of thousands fans, who lined the streets of downtown San Francisco. The parade ends at City Hall.

The party started early in Civic Center park, with many showing up hours before the 5 p.m. game on a nice Indian Summer day in San Francisco.

The city's ubiquitous food trucks did a brisk business and drummers of all types beat their instruments throughout the game.

"Where else in the world do you want to be tonight," replied Dave Wormald of Toronto. Wormald and two other colleagues were in town for a business meeting and were watching the game at their hotel when they decided to embark for City Hall.

"This is the place to be," said Jim Vliet, Wormald's colleague.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-10-29-World%20Series-Giants%20Fans/id-4e062b7c91cd4fa4af37fdef705d2e00

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Peanut Butter Whoopie Pies from Tv Food and Drink - Brought to ...

Also known as ?gobs,? ?bobs? ?black-and-whites? and ?BFO?S? (Big Fat Oreos), the whoopie pie is the official ?state treat? of Maine. ?These cakey cookies exploding with buttercream have never had their origins fully explained, though most attribute it to Pennsylvania Dutch country.

My sister Jodi and I recently had an all-day marathon cookie making session that included carrot cake cookies (see them here), chocolate mint sandwich cookies (here), and these peanut butter whoopie pies. ?Working side by side, we quickly reverted to the traditional roles we held growing up within the structure of the Green family. ?She transformed into the bossy taskmaster who knows better than everyone else, while I became the whiney ?mistake child? who resorts to raising his voice and cutting other people off in an effort to have his opinion respected. ?If you don?t believe me, check out the VIDEO PROOF below.

The combination of my sister?s and my family-fostered dysfunction and rampant insecurities appears to have worked wonders! ?By the end of the day we had something along the lines of 300 cookies cooling on dishes and parchment paper slices all over my home. ?And they all turned out pretty spectacular, plus we were still speaking to one another. There was a brief ?missing acrylic fingernail? panic, but what kitchen experience is complete without one of those?

Peanut Butter Whoopie Pies from Martha Stewart

• 1 3/4 cups all-purpose flour
• 3/4 cup unsweetened cocoa powder (not Dutch process)
• 1 1/2 teaspoons baking soda
• 1/2 teaspoon fine salt
• 4 tablespoons unsalted butter, softened
• 1/4 cup vegetable shortening
• 1/2 cup granulated sugar
• 1/2 cup packed dark-brown sugar
• 1 large egg
• 1 cup whole milk
• 1 teaspoon pure vanilla extract
• Peanut Butter Buttercream (recipe below)
• 2 ounces bittersweet chocolate, finely chopped

Peanut Butter Buttercream

• 2/3 cup natural, creamy peanut butter
• 8 tablespoons (1 stick) unsalted butter, softened
• 3/4 cup confectioners? sugar
• Fine salt (optional)

Cream peanut butter and butter in the bowl of an electric mixer fitted with the paddle attachment on high speed. On low speed, mix in sugar until combined, then beat mixture on high speed until fluffy and smooth, about 3 minutes. Add salt to taste, if desired. Use immediately.

Preheat oven to 375 degrees. Line two large baking sheets with parchment paper; set aside. Sift together flour, cocoa, baking soda, and salt into a small bowl; set aside.

Add butter, shortening, and sugars to the bowl of an electric mixer fitted with the paddle attachment; cream on high speed until smooth, about 3 minutes. Add egg; beat until pale and fluffy, about 2 minutes. Add half the flour mixture, then the milk and vanilla; beat until combined. Add the remaining flour mixture. Beat together, scraping down sides of bowl with a rubber spatula as needed.

Drop 12 slightly rounded tablespoons of batter 2 inches apart on each baking sheet. Bake the cookies in the upper and lower thirds of oven, 10 minutes; switch the positions of the baking sheets, and rotate each one. Continue baking until the cookies spring back to the touch, 2 to 4 minutes more.

Remove from oven; let cookies cool on baking sheets, 10 minutes.Transfer with a metal spatula to a wire rack; let cool completely. Meanwhile, line a cooled baking sheet with a new piece of parchment; repeat process with remaining batter.

Spread 1 scant tablespoon buttercream on flat sides of half the cookies. Top each with one of the remaining cookies, flat side down, and gently press together. Transfer pies to a tray.

Cookies can be refrigerated in single layers (they?re sticky!) for up to three days. Bring to room temperature before serving.

Read More ?- Dancing with the Stars, Bachelorette, Bachelor Pad and more

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Tags: Buttercream recipes, Christmas cookies, cookies for kids, Martha Stewart cookies, Martha Stewart recipes, Peanut Butter Buttercream recipe, peanut butter cookies, peanut butter whoopie pies, thanksgiving cookies

Posted in Cookie Season and Desserts and Homemade 3 hours, 43 minutes ago at 9:28 am. 2 comments

Source: http://tvfoodanddrink.com/2012/10/season-cookie-peanut-butter-whoopie-pies/

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Project / Program / Engagement Manager Europe: DPI / Big Data ...

Basic Salary: ? ?70-95K + Bonus + bens

OTE: ?

Location: UK,

Job Type: Permanent/Full Time

Details

Job Title: Project / Program / Engagement Manager Europe: DPI / Big Data / Telco Analytics
Package: ?70-95K + Bonus + bens
Location: UK, London, South West

Our client provides solutions for timely, big data decision-making for international Telco?s and Service Providers and is growing rapidly.

Off the back of recent successes they are looking to hire an experienced international projects / program / engagement manager to manage deployments across European (tier 1) Service provider clients that they work with.

Essential role highlights:
? Responsible for managing customer projects to time, budget, contracted deliverables and overall customer satisfaction.
? Serve as an engagement and program manager to ensure successful implementations that may cross multiple geographic locations with diverse teams from various customer teams as well as adjacent third party vendors and partners.
? Manage a number of projects concurrently depending upon project scope from contract/sow through to full acceptance and revenue recognition.
? Engagement Managers will also be critical to finding new revenue and follow on business opportunities. P&L management will also become an important future responsibility.

Job Responsibilities
? Create and maintain the overall delivery plan from contract and sow to full acceptance by the customer
? Create and foster close customer relationships to effectively manage schedule, scope, tradeoffs and issues resolution
? Manage and drive competing requests across simultaneous client engagements
? Identify and drive project activities from across customer functional groups and partner sources
? Facilitate and drive internal communications within the sales, engineering, services, support and product management organizations. Ensure efficient handoffs between functions.
? Manage project to time, budget, and contracted deliverables (including planning, scheduling, milestone reviews, etc.)
? Help to document best practices in developing and deploying solutions
? Coordinate external communications with Customers and third party vendors on meeting the program objectives and to protect company interests.
? Broaden the reach of customer accounts by investigating new opportunities for our solutions.
? Drive project reviews for management and customers
? Manage project P&L to targeted margin results

Skills Needed
? At least 8-12+ years experience in customer-facing positions in a professional services role /firm.
? Experience with modern services deployment methodologies such as Agile/Scrum, with emphasis on software and hardware architecture, and infrastructure design and development
? Use of formal project management tools (e.g., MS-Project, Visio, etc.)
? Strong technical background, with previous experience with delivery of Enterprise class (Telco) software
? Experience in data warehousing or business intelligence application is desired (Oracle, SiteCatalyst, SAP, IBM/Cognos, etc.)
? Exposure to Telecom/Cable/Wireless service delivery and/or IP data networking.
? Strong analytical skills regarding technical and project management issues
? Strong organizational skills with an ability to manage competing client demands
? Ability to interact and communicate with CIO-level personnel
? Excellent communications and interpersonal skills
? Project Management certification and ITIL certification preferred

For More information, please feel free to get in touch.

Apply for this Job

Please complete the form below to apply for this job and to send us your CV/Resume.

Source: http://www.mtech-europe.com/news/project-program-engagement-manager-europe-dpi-big-data-telco-analytics/

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Average U.S. retail gas prices drop 8 cents in two weeks

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The Advantage of Email Marketing | Software Versions

Expanding your business can be difficult and easy as it depends on how you would like to get the marketing strategies. To save up your money, you can create and planning the marketing strategy on your own although it is going to be difficult and seize most of your time, or you can get the service from the iContact service. If you never heard about the aforementioned service, perhaps you know it with different term and that would be the online directory email marketing. Many small businesses are using the online directory email marketing not only to expand their business, but also to get potential clients to market both their products and their service.

What advantages that you can get by using the aforementioned service? There are many advantages that you can get and one of them is that you don?t have to hire professional marketing team to help you build the marketing strategies for you. Hiring professional marketing team is definitely going to be expensive by if you are using the email marketing by iContact, you probably only have to pay half instead of paying expensive work contract with the aforementioned marketing team.

Another advantage that you can get is that the amount of time you can save in choosing which emails that you wish to contact. The email marketing with iContact means that you are going to have everything in single click without don?t have to schedule marketing meeting and waiting for brainstorming that eventually will provide you with list of possible marketing strategies. But with the aforementioned marketing email provider, you can immediately access the email lists that you want to have because the provider is categorized based on different business fields such as health, companies and manufacturers, and many more. This could be not only the most effective marketing strategy that you have to get, but also full-proof as you can reach your potential clients almost directly through their email.

This entry was posted on October 21, 2012, 10:25 am and is filed under Internet Marketing. You can follow any responses to this entry through RSS 2.0. Both comments and pings are currently closed.

Source: http://www.statsdawg.org/the-advantage-of-email-marketing.html

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An Incredible Film From NASA: Gradient Sun (Little green footballs)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/257043851?client_source=feed&format=rss

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Floods in France prompt evacuations in shrine town

PARIS (AP) ? Pilgrims trek by the millions each year to the Roman Catholic shrine in Lourdes, many looking to drink its spring waters reputed for their healing powers. This time, visitors were fleeing a different kind of water ? floodwaters ? in the southwestern French town.

Rescue teams helped hundreds of pilgrims escape waterlogged hotels on Saturday after heavy rains led the Gave River to overrun its banks ? and even wash up into the town's famed grotto, where many Catholics believe the Virgin Mary appeared to a 14-year-old girl named Bernadette Soubirous in 1858.

The regional government issued a statement late Saturday saying 427 people had been evacuated from their hotels. The Red Cross and regional authorities provided food and shelter to the escapees, as authorities warned of forecasts for more rain in the region.

In one televised image, a rescuer waded waist-deep into a hotel lobby with a red boat in tow and teams helped elderly visitors inside for a trip to higher ground. Others showed a fast-flowing, white-water river rumbling through the town, and the grotto ? or cave ? was filled with about 1.5 meters of water, under a niche statute of the Virgin Mary.

Visits to the grotto were temporarily suspended. Officials say the town draws about 6 million visitors a year ? mainly looking to see the grotto. The shrine has special meaning for the suffering, many of whom believe its spring water can heal and even work miracles.

Thierry Castillo, director of the nearby Lourdes sanctuary, said visitors had shown "understanding" and predicted that the grotto would remain closed at least through Monday.

Source: http://news.yahoo.com/floods-france-prompt-evacuations-shrine-town-201259854.html

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Source: http://workathomeandmakemoney.org/poker-apparel-affiliate-program/

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Rape victims struggle to get legal abortions in Argentina | Bioethics ...

[Reuters] Rape victims have a right to abortion under Argentine law, but the nation?s Supreme Court was forced to intervene this week to ensure that a woman who says she was kidnapped, forced into prostitution and raped could end her pregnancy.

The case has divided the public and sparked lawsuits in Buenos Aires, one of Latin America?s most socially liberal cities where the mayor and opposition lawmakers are fighting over what limits if any should be placed on the procedure.

Abortion is banned in much of Latin America, home to about half the world?s Roman Catholics. Argentina is among the countries that allow abortions in cases of rape or when a woman?s health is in danger.

The recent controversy began when Buenos Aires Mayor Mauricio Macri announced that the city?s first legal abortion under a new regulation governing the procedure in rape cases would be carried out on Tuesday.

But a civil court judge blocked the abortion at the last minute at the request of a private group.

Anti-abortion activists identified the woman and protested outside her home last week and then again at the hospital where she was to have the abortion. The woman?s lawyer, Pablo Vicente, said the hospital chaplain was among the protesters.

?This woman was the victim of human trafficking, she has been raped and she doesn?t want to continue with her pregnancy, which is now in the ninth week of gestation,? Vicente said. ?She had to endure a protest at her home and her family didn?t know the whole story of what had happened to her, so she has unnecessarily had to relive humiliations of all kinds.?

In an urgent ruling on Thursday the Supreme Court overturned the lower court?s decision and said the abortion could proceed.

The woman, whose name has not been made public, could terminate her pregnancy as early as Friday. Rights group Amnesty International said the delays amounted to ?cruel, inhuman and degrading treatment.?

In March, the Supreme Court ruled that abortion was legal for all rape victims and said a sworn affidavit by the women or their legal representatives would be sufficient to show the pregnancy resulted from rape.

Since then, provincial governments and the city of Buenos Aires have drafted regulations to implement the ruling. Last month, Macri?s government issued a protocol allowing abortions during the first 12 weeks of a rape victim?s pregnancy.

Opponents, some of whom favor broadly legalizing abortion, responded by narrowly passing a bill in the city?s legislature to scrap that time limit and allow girls 14 and older to abort without parental consent, arguing that most rape-related pregnancies occurred when girls were molested by relatives.

Macri, a centre-right politician whose party is generally opposed to abortion, has vowed to veto the bill, leaving the new protocol in place. Other provinces have set other conditions for rape victims to get access to legal abortions, prompting calls by feminist activists to enforce the same guidelines nationwide.

?Depending on where a woman lives, she either has this right or she doesn?t, which is something we can?t permit,? said Mabel Bianco, head of the Foundation for Women?s Study and Research (FEIM), a non-profit group that advocates gender equality and women?s rights.

BATTLE OVER RIGHTS

Pedro Andereggen, a lawyer for the Association for the Promotion and Defense of the Family, which led the legal campaign against this week?s abortion, said his group was fighting for unborn children?s rights and hoped courts throughout Argentina would ignore the Supreme Court ruling.

?The mother doesn?t have the right to kill her child, even when she?s been the victim of rape. The right to life of an innocent human being is absolute and allows no exceptions whatsoever,? Andereggen said.

In Latin America, 95 percent of abortions are unsafe, according to a study co-sponsored by the World Health Organization. Only Cuba and Guyana permit abortions in the case of normal pregnancies.

In Argentina, roughly 500,000 abortions and miscarriages take place each year, FEIM estimates. Many wealthier Argentine women get abortions in private clinics under the pretense of having their appendix removed.

?Poor women go to the hospital, they can?t get an abortion there and so they do it in an unsafe way and either end up very sick or dead. This is the great hypocrisy and great social injustice of abortion,? Bianco said.

Debate on legalizing abortion has made little headway in Argentina due in part to President Cristina Fernandez?s opposition. Catholic leaders condemn abortion under any circumstances and many people share their beliefs.

?Today I can say I?m not openly in favor of abortion,? said Maria Elena Leuzzi, a Catholic who founded a non-profit group to help rape victims after her daughter was raped and savagely beaten in 2001. Her daughter did not become pregnant.

?But if you had asked me in 2001, I?m not going to be a hypocrite ? I may have wanted my daughter to abort. Because what was I going to do with my daughter raped, traumatized, unhinged, with several suicide attempts, not knowing where that baby came from or what it could bring to the world genetically. It?s difficult.?

(Editing by Paul Simao)

?

Source: http://www.bioethicsinternational.org/blog/2012/10/18/rape-victims-struggle-to-get-legal-abortions-in-argentina/

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Young blood really is the key to youth

HUMANS are constantly searching for an elixir of youth - could it be that an infusion of young blood holds the key?

This seems to be true for mice, at least. According to research presented this week at the Society for Neuroscience conference in New Orleans, Louisiana, giving young blood to old mice can reverse some of the effects of age-related cognitive decline.

Last year, Saul Villeda, then at Stanford University in California, and colleagues showed they could boost the growth of new cells in the brains of old mice by giving them a blood infusion from young mice (Nature, doi.org/c9jwvm).

"We know that blood has this huge effect on brain cells, but we didn't know if its effects extended beyond cell regeneration," he says.

Now the team has tested for changes in cognition by linking the circulatory systems of young and old mice. Once the blood of each conjoined mouse had fully mixed with the other, the researchers analysed their brains.

Tissue from the hippocampus of old mice given young blood showed changes in the expression of 200 to 300 genes, particularly in those involved in synaptic plasticity, which underpins learning and memory. They also found changes in some proteins involved in nerve growth.

The infusion of young blood also boosted the number and strength of neuronal connections in an area of the brain where new cells do not grow. This didn't happen when old mice received old blood.

To find out whether these changes improved cognition, the team gave 12 old mice eight intravenous shots of blood plasma either from a young or an old mouse, over the course of one month. They used plasma rather than whole blood to exclude any effect produced by blood cells.

The mice then took part in a standard memory task to locate a hidden platform in water. The old mice that had received young blood plasma remembered where to find the platform much quicker than the mice on the old plasma.

To find out which brain area was involved in this reversal of cognitive decline, the team performed fear conditioning tests. Mice that had been given young blood were better at remembering fear associated with tasks that activated the hippocampus, suggesting that young blood has a specific effect on this area of the brain.

But the mystery remains: what exactly is it about young blood that old blood doesn't have? "We have not identified any individual factors responsible for the rejuvenating effects of young plasma yet," says Tony Wyss-Coray, also at Stanford. His team is now trying to identify possible candidates such as lipids and hormones.

Villeda is hopeful the results might one day translate to humans since the components of blood that change with age in mice mirror those in humans.

While "it's plausible that similar mechanisms operate in humans," says Joseph Quinn at Oregon Health and Science University in Portland, there is no evidence yet to support this.

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Google?s $99 Nexus tablet will reportedly launch ahead of the holidays

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Sweden protests to Israel over Iran sanctions comments

STOCKHOLM (Reuters) - Sweden has complained to Israel over a newspaper report which said the Nordic state had tried to block EU sanctions against Iran to protect powerhouse telecoms equipment maker Ericsson, the Foreign Ministry said on Tuesday.

The report on Sunday, in daily Haaretz, quoted an Israeli Foreign Ministry official as saying Sweden wanted to prevent a European Union decision to impose further sanctions on Iran. The sanctions were eventually agreed on Tuesday.

Swedish Foreign Ministry spokesman Anders Jorle said the Israeli ambassador had been summoned on Monday.

"The reason was the somewhat odd comments from the Israeli Foreign Ministry's spokesperson," he said. "We expressed our view on this and the reply was that they regretted the comments and that they were not an official Israeli position."

Haaretz had quoted a Foreign Ministry official as saying that if Ericsson lost a deal in Iran then other business transactions, such as in China, could suffer.

Foreign Minister Carl Bildt on Monday said the comments were a smear on Swedish policy and were "entirely wrong".

"They must have got this from their own fairy tale factory. Sweden and Israel may have different opinions in some matters but this isn't the way to handle our dialogue," he said.

Ericsson, the world's biggest telecom equipment maker with three customers in Iran - MTN Irancell, MCCI and TIC - denied having new orders in the works in the country.

"That's a lie, it's wrong," Ericsson spokesman Fredrik Hallstan said. "Since the sanctions against the financial sector came into force in 2010 we don't take any new business in Iran. We are honoring existing contracts."

(Reporting by Anna Ringstrom; Additional reporting by Simon Johnson, and by Crispian Balmer in Jerusalem; Editing by Jon Hemming)

Source: http://news.yahoo.com/sweden-protests-israel-over-iran-sanctions-comments-130722276.html

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Marriage, education can help improve well-being of adults abused as children

ScienceDaily (Oct. 16, 2012) ? Researchers investigating the long-term consequences of child abuse have identified some protective factors that can improve the health of victims during their adulthood.

Men and women in their 30s who had been abused or neglected as children reported worse mental and physical health than their non-abused peers. But being married or having graduated from high school buffered the severity of their symptoms.

The researchers also found that adults who experienced child abuse reported less happiness and self-esteem, more anger and other psychological damage, indicating child abuse has wider-ranging effects than previously known.

"As we understand more of how individuals overcome early trauma, we can develop programs to support and nurture kids exposed to abuse," said Todd Herrenkohl, professor in the University of Washington's School of Social Work.

Herrenkohl is the lead author of two new studies examining what factors can mitigate the harm of maltreatment during childhood. He used data from the Lehigh Longitudinal Study, which began in the 1970s to evaluate the consequences of experiencing violence at a young age.

Participants became involved in the study if their parents were reported to child welfare agencies for abuse or neglect. Parents were also asked about a range of disciplinary practices that are considered abusive, such as slapping and leaving a bruise, kicking, hitting or biting. Neglect involved depriving children of necessities, such as food, medical attention and hygiene.

The study's participants, an even mix of men and women, are now in their late 30s. Herrenkohl and his collaborators got back in touch with them, and interviewed more than 80 percent of the original participants, about half of whom were earlier abused. The researchers wanted to know how the participants were faring in their adult lives and asked about mental and physical health, use of drugs and alcohol, quality of relationships with family and friends, education, employment and overall well-being and satisfaction in life.

In a study published online Sept. 28 in the Journal of Family Violence, Herrenkohl and his co-authors reported that childhood abuse led to worse mental and physical health and substance abuse in adulthood. For instance, 24 percent of child abuse survivors reported moderate to severe depression -- a level that could be debilitating -- compared with 7 percent of participants who had not been abused.

About 19 percent of the survivors reported problems with alcohol over their lifetimes, whereas only 10 percent of the non-abused participants reported these problems.

Being married or a high-school graduate partly lowered, but did not eliminate, the risk for depression among those who had been abused. Survivors who graduated high school had a lower risk for lifetime alcohol problems.

Surprisingly, gender and early childhood socioeconomic status had little bearing on the long-term effects of abuse. "The expectation is that growing up in a household with a higher income and higher social status will help kids, but child maltreatment erases those advantages," Herrenkohl said.

In a second study, published in the November issue of Violence and Victims and also based on interviews with the adults from the Lehigh Longitudinal Study, Herrenkohl and his co-authors explored anger proneness, self-esteem, sense of independence, satisfaction in life and other measures of well-being that studies of child abuse typically ignore. Child maltreatment was linked to lower scores on most of these well-being measures when compared with scores from individuals who hadn't been abused.

"The results show that the effects of child maltreatment extend beyond the most common mental health diagnoses," Herrenkohl said. "It shows that adults abused as children experience the emotional consequences of early trauma well into their adult years."

The paper published in the Journal of Family Violence was funded by the National Institute of Child Health and Human Development, the Office of Behavioral and Social Sciences Research, and the National Institute on Drug Abuse -- all part of the National Institutes of Health. Co-authors are Seunghye Hong of the University of Hawaii, Bart Klika of UW, and Roy Herrenkohl (Todd Herrenkohl's father) and M. Jean Russo of Lehigh University.

The paper published in Violence and Victims was funded by the National Institute of Child Health and Human Development. Klika, Roy Herrenkohl, Russo and Tamara Dee, formerly of UW, were co-authors.

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Journal References:

1. Todd I. Herrenkohl, Seunghye Hong, J. Bart Klika, Roy C. Herrenkohl, M. Jean Russo. Developmental Impacts of Child Abuse and Neglect Related to Adult Mental Health, Substance Use, and Physical Health. Journal of Family Violence, 2012; DOI: 10.1007/s10896-012-9474-9
2. Todd I. Herrenkohl, J. Bart Klika, Roy C. Herrenkohl, M. Jean Russo, Tamara Dee. A Prospective Investigation of the Relationship Between Child Maltreatment and Indicators of Adult Psychological Well-Being. Violence and Victims, 2012; 27 (5): 764 DOI: 10.1891/0886-6708.27.5.764

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/mental_health/~3/JbEdgEzCvDQ/121016125242.htm

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After Diabetes During Pregnancy, Healthy Diet Linked to Reduced ...

NIH-supported study first to show reduced risk solely through dietary modification

Bethesda, Maryland--(ENEWSPF)--October 9, 2012. ?By sticking to a healthy diet in the years after pregnancy, women who develop diabetes during pregnancy can greatly reduce their risk of developing type 2 diabetes, a study supported by the National Institutes of Health has found.

Previously, it was not known how much the risk for type 2 diabetes in these women could be lowered through adhering to healthy diet.

In about 5 percent of U.S. pregnancies, women who do nothave diabetes before becoming pregnant develop high blood sugar levels in pregnancy. This condition, called gestational diabetes, raises a woman's risk of developing type 2 diabetes later in life up to sevenfold, compared to pregnant women who don't have gestational diabetes. Little is known about the role healthy lifestyle factors may have in preventing progression from gestational diabetes to type 2 diabetes later in life.

The study found the greatest reductions in type 2 diabetes risk were for women who followed diets rich in whole grains, fresh fruits, vegetables, and legumes, and included poultry, seafood, and nuts, with limiting intake of red and processed meats. Those who followed this type of diet in the years after having gestational diabetes consistently reduced their risk by about half that of women who did not.

"Our findings indicate that women with gestational diabetes aren't necessarily preordained to develop type 2 diabetes," said senior author Cuilin Zhang, M.D., Ph.D., of the Epidemiology Branch at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the NIH institute where much of the analysis was conducted. "It appears they may have some degree of control. Sticking to a healthy diet may greatly reduce their chances for developing diabetes later in life."

In addition to Dr. Zhang's role in the study, funding support was provided by the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (grants DK058845 and P30 DK046200-18) and the National Cancer Institute (grant CA58305).

Dr. Zhang led the multidisciplinary team that conducted the study, including the first author Deirdre K. Tobias, Sc.D., and colleagues Frank B. Hu, M.D., Ph.D., Jorge Chavarro, M.D., Sc.D., Bernard Rosner, Ph.D., and Dariush Mozaffarian, M.D., D.P.H., of the Harvard School of Public Health, Boston. Drs. Hu, Chavarro, Rosner and Mozaffarian are also affiliated with the Brigham and Women's Hospital and Harvard Medical School.

The study appears online in the Archives of Internal Medicine.

The body uses insulin, produced in the pancreas, to move the sugar glucose from the blood and into the cells. In people with type 2 diabetes, cells do not respond appropriately to insulin, and, if untreated, blood sugar reaches high levels. Complications of diabetes include heart disease, stroke, kidney disease, blindness and amputation.

Research has shown that, among the general population, healthy eating can reduce the risk of developing type 2 diabetes. Dr. Zhang and her colleagues have shown previously that, before they conceive, women who follow a diet low in cholesterol and animal fat, low in sugar sweetened beverages, but high in fiber, and who are physically active have a reduced risk of gestational diabetes.

This study included 4,413 women who developed gestational diabetes between 1991 and 2001. The women were taking part in a long-term study of nurses called the Nurses' Health Study II. As part of the ongoing study, the nurses filled out questionnaires every other year on lifestyle and health. They completed a questionnaire every four years about their intake of several common food items during the previous year.

The researchers ranked the women?s responses in terms of how closely they adhered to three widely studied diets: a Mediterranean-style diet, the Dietary Approaches to Stop Hypertension ? or DASH ? diet and the Healthy Eating Index, a measure of how closely an individual follows the healthy eating guidelines developed by the United States Department of Agriculture. All three diets promote eating fruits, vegetables, nuts, legumes and whole grains.

Of the women in the study, 491 later developed type 2 diabetes. The researchers found that women who adhered most closely to these diets (scores in the top 25 percent) lowered their risk for type 2 diabetes considerably when compared to the least compliant group (lowest 25 percent) :

Mediterranean Diet (40 percent lower risk)
Dash Diet(46 percent lower risk)
Healthy Eating Index pattern (57 percent lower risk)

On average, these women developed type 2 diabetes about 14 years after they had experienced gestational diabetes.

"Our findings suggest that reaching out to women who have had gestational diabetes on the importance of a healthy diet might significantly reduce the overall rate of type 2 diabetes," Dr. Tobias said.

Some women in the study who adhered to a healthy diet still developed type 2 diabetes. Dr. Zhang said her team is evaluating other factors, such as genes and physical activity levels and the interaction between genes and diet and lifestyle factors, that might affect a woman's diabetes risk as well, in a large ongoing study on U.S. and Danish women (Diabetes & Women's Health Study, http://www.dwhstudy.org) supported by the NICHD.

About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): The NICHD sponsors research on development, before and after birth; maternal, child, and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visit the Institute's website at http://www.nichd.nih.gov/.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.?

Source: nih.gov

Source: http://www.enewspf.com/latest-news/health-and-fitness/37257-after-diabetes-during-pregnancy-healthy-diet-linked-to-reduced-type-2-diabetes-risk.html

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Nobel prize to Briton, Japanese for stem cell work

STOCKHOLM (AP) ? Two scientists from different generations won the Nobel Prize in medicine Monday for the groundbreaking discovery that cells in the body can be reprogrammed to become completely different kinds, potentially opening the door to growing customized tissues for treatments.

The work of British researcher John Gurdon and Japanese scientist Shinya Yamanaka ? who was born the year Gurdon made his discovery ? has raised hopes of developing transplant tissue to treat diseases like Parkinson's and diabetes. And it has spurred a new generation of laboratory studies into other diseases, including schizophrenia, that may lead to new treatments.

Basically, their work paved the way to making the equivalent of embryonic stem cells without the ethical questions the embryonic cells pose.

"Their findings have revolutionized our understanding of how cells and organisms develop," the Nobel committee at Stockholm's Karolinska Institute said in announcing the 8 million kronor ($1.2 million) award. It was the first of this year's Nobel Prizes, with five more awards to be announced by next Monday.

Gurdon, 79, showed in 1962 that the DNA from specialized cells of frogs, like skin or intestinal cells, could be used to generate new tadpoles. That showed the DNA still had its ability to drive the formation of all cells of the body.

At the time, the discovery had "no obvious therapeutic benefit at all," Gurdon told reporters in London. "It was almost 50 years before the value ? the potential value ? of that basic scientific research comes to light."

In 1997, the cloning of Dolly the sheep by other scientists showed that the same process Gurdon discovered in frogs would work in mammals.

More than 40 years after Gurdon's discovery, in 2006, Yamanaka, 50, showed that a surprisingly simple recipe could turn mature cells back into primitive cells, which in turn could be prodded into different kinds of mature cells.

Basically, the primitive cells were the equivalent of embryonic stem cells, which had been embroiled in controversy because to get human embryonic cells, human embryos had to be destroyed. Yamanaka's method provided a way to get such primitive cells without destroying embryos.

"The discoveries of Gurdon and Yamanaka have shown that specialized cells can turn back the developmental clock under certain circumstances," the committee said. "These discoveries have also provided new tools for scientists around the world and led to remarkable progress in many areas of medicine."

Just last week, Japanese scientists reported using Yamanaka's approach to turn skin cells from mice into eggs that produced baby mice.

Gurdon has served as a professor of cell biology at Cambridge University's Magdalene College and is currently at the Gurdon Institute in Cambridge, which he founded. Yamanaka worked at the Gladstone Institute in San Francisco and Nara Institute of Science and Technology in Japan. He is currently at Kyoto University and also affiliated with the Gladstone Institute. Yamanaka is the first Japanese scientist to win the Nobel medicine award since 1987.

Gurdon said he first thought someone was "pulling my leg" when he got the call from the Nobel committee. He said he planned to celebrate with a drink, but expected to be back in the lab Tuesday morning and that he had no plans to retire.

Yamanaka told Japanese broadcaster NHK that he was at home doing chores on Monday when he got the call from Stockholm. "Even though we have received this prize, we have not really accomplished what we need to. I feel a deep sense of duty and responsibility," Yamanaka said.

Choosing Yamanaka as a Nobel winner just six years after his discovery was unusual. The Nobel committees typically reward research done more than a decade before, to make sure it has stood the test of time.

In 2010, the Nobel Prize in physics went to two researchers whose discoveries were also published six years earlier. In 2006, two American scientists won the medicine prize eight years after their work was published.

Prize committee member Juleen Zierath said Gurdon and Yamanaka's discoveries, which also earned them a Lasker award for basic research in 2009, could hold "immense potential," including in developing treatments for Parkinson's disease and in making cells that produce insulin. However, she added that therapeutic implications are still far away.

The idea of reprograming cells has also been put to work in basic research on disease, through an approach sometimes called "disease in a dish."

The reprogramming allows scientists to create particular kinds of tissue they want to study, like lung tissue for studying cystic fibrosis, or brain tissue for Huntington's disease. By reprogramming cells from patients with a particular disease, they can create new tissue with the same genetic background, and study it in the lab. That can give new insights into the roots of the problem.

In addition, that approach allows them to screen drugs in the lab for possible new medicines.

Experts welcomed the announcement, praising the duo for their groundbreaking and influential discoveries in a field riddled with ethical debates.

"Everyone who works on developmental biology and on the understanding of disease mechanisms will applaud these excellent and clear choices for the Nobel Prizes," said John Hardy, professor of Neuroscience at University College London. "Countless labs' work builds on the breakthroughs they have pioneered."

Yamanaka deserves extra credit for overcoming fierce objections to the creation of embryos for research, reviving the field, said Julian Savulescu, director of Oxford University's Uehiro Centre for Practical Ethics.

"Yamanaka has taken people's ethical concerns seriously about embryo research and modified the trajectory of research into a path that is acceptable for all," Savulescu said. "He deserves not only a Nobel Prize for Medicine, but a Nobel Prize for Ethics."

Goran Hansson, the secretary of the prize committee, said he had reached both winners by phone before the announcement. He said they were looking forward to coming to Stockholm to collect the award in a ceremony on Dec. 10, the anniversary of prize founder Alfred Nobel's death in 1896.

The medicine award was the first Nobel Prize to be announced this year. The physics award will be announced Tuesday, followed by chemistry on Wednesday, literature on Thursday and the Nobel Peace Prize on Friday.

The economics prize, which was not among the original awards, but was established by the Swedish central bank in 1968, will be announced on Oct. 15.

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Associated Press science writer Malcolm Ritter in New York; AP writers Cassandra Vinograd and Raphael Satter in London; and AP writer Elaine Kurtenbach in Tokyo contributed to this report.

Source: http://news.yahoo.com/nobel-prize-briton-japanese-stem-cell-111153957.html

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